Goals either side of half-time from Samir Nasri and Vincent Kompany saw City capture the title with an easy victory.
Manuel Pellegrini's side led second-place Liverpool by only two points in the league heading into the match.
But their sizeable goal difference meant a draw against West Ham at Etihad Stadium would be enough to take the title
The title is Man City's second in three seasons.
For Liverpool, only victory over Newcastle United and a shock West Ham win could have seen them finish the season on top.
Liverpool trailed after an early own goal from Martin Skrtel, however two goals in the second half - from Daniel Agger and Daniel Sturridge - secured second place in the league.
Man City received a boost for their final match with the return of Argentine striker Sergio Aguero from a groin injury.
Aguero's return was the only change from the City side which beat Aston Villa 4-0 mid-week.
But it was Nasri who broke through West Ham's defences six minutes before the interval, taking aim from 20 yards with a powerful shot which went in off the post.
The goal was followed by another four minutes into the second half when Kompany struck home from six yards after Edin Dzeko won the ball from a corner.
Aguero had two chances to extend City's lead, but his header sailed wide at the near post and he later failed to score before an open goal from a Zabaleta cross.
In other key matches, Norwich City's relegation was confirmed after a 2-0 defeat to Arsenal.
Cardiff City also bowed out of the Premier League after a 2-1 defeat at the hands of Chelsea.
Tottenham secured a place in the Europa League for next season with a 3-0 win over Aston Villa.
